Find Oregon: Nabumetone

nab-UE-me-tone

Oral route(Tablet)

NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may be increased in patients with cardiovascular disease or risk factors for cardiovascular disease. Nabumetone is contraindicated for the treatment of perioperative pain in the setting of CABG surgery. NSAIDs can also cause an increased risk of serious gastrointestinal adverse events especially in the elderly, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal .

Commonly used brand name(s)

In the U.S.

Relafen

Available Dosage Forms:

Tablet

Therapeutic Class: Analgesic

Pharmacologic Class: NSAID

Chemical Class: Acetic Acid (class)

Uses For nabumetone

Nabumetone is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain and help relieve symptoms of arthritis (osteoarthritis and rheumatoid arthritis), such as inflammation, swelling, stiffness, and joint pain. nabumetone does not cure arthritis and will help you only as long as you continue to take it .

nabumetone is available only with your doctor's prescription .

Before Using nabumetone

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For nabumetone, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to nabumetone or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of nabumetone in the pediatric population. Safety and efficacy have not been established .

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of nabumetone in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution in patients receiving nabumetone .

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking nabumetone, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using nabumetone with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Ketorolac

Pentoxifylline

Using nabumetone with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Abciximab

Ardeparin

Argatroban

Beta Glucan

Bivalirudin

Certoparin

Cilostazol

Citalopram

Clopidogrel

Clovoxamine

Dabigatran Etexilate

Dalteparin

Danaparoid

Desirudin

Dipyridamole

Enoxaparin

Escitalopram

Femoxetine

Flesinoxan

Fluoxetine

Fluvoxamine

Fondaparinux

Ginkgo

Heparin

Lepirudin

Methotrexate

Nadroparin

Nefazodone

Parnaparin

Paroxetine

Pemetrexed

Protein C

Reviparin

Rivaroxaban

Sertraline

Sibutramine

Tacrolimus

Ticlopidine

Tinzaparin

Tirofiban

Vilazodone

Zimeldine

Using nabumetone with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acebutolol

Acetohexamide

Alacepril

Alprenolol

Amiloride

Arotinolol

Atenolol

Azilsartan Medoxomil

Azosemide

Befunolol

Bemetizide

Benazepril

Bendroflumethiazide

Benzthiazide

Betaxolol

Bevantolol

Bisoprolol

Bopindolol

Bucindolol

Bumetanide

Bupranolol

Buthiazide

Candesartan Cilexetil

Canrenoate

Captopril

Carteolol

Carvedilol

Celiprolol

Chlorothiazide

Chlorpropamide

Chlorthalidone

Cilazapril

Clopamide

Cyclopenthiazide

Cyclosporine

Delapril

Desvenlafaxine

Dicumarol

Dilevalol

Duloxetine

Enalaprilat

Enalapril Maleate

Eprosartan

Esmolol

Ethacrynic Acid

Fosinopril

Furosemide

Gliclazide

Glimepiride

Glipizide

Gliquidone

Glyburide

Hydrochlorothiazide

Hydroflumethiazide

Imidapril

Indapamide

Irbesartan

Labetalol

Landiolol

Levobetaxolol

Levobunolol

Lisinopril

Losartan

Mepindolol

Methyclothiazide

Metipranolol

Metolazone

Metoprolol

Milnacipran

Moexipril

Nadolol

Nebivolol

Nipradilol

Olmesartan Medoxomil

Oxprenolol

Penbutolol

Pentopril

Perindopril

Phenprocoumon

Pindolol

Piretanide

Polythiazide

Propranolol

Quinapril

Ramipril

Sotalol

Spirapril

Spironolactone

Talinolol

Tasosartan

Telmisartan

Temocapril

Tertatolol

Timolol

Tolazamide

Tolbutamide

Torsemide

Trandolapril

Triamterene

Trichlormethiazide

Valsartan

Venlafaxine

Xipamide

Zofenopril

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of nabumetone

For safe and effective use of nabumetone, do not take more of it, do not take it more often, and do not take it for a longer time than ordered by your doctor. Taking too much of nabumetone may increase the chance of unwanted effects, especially in elderly patients .

When used for severe or continuing arthritis, nabumetone must be taken regularly as ordered by your doctor in order for it to help you. nabumetone usually begins to work within one week, but in severe cases up to two weeks or even longer may pass before you begin to feel better. Also, several weeks may pass before you feel the full effects of nabumetone.

You may take nabumetone with or without food .

Dosing

The dose of nabumetone will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of nabumetone. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablets):
- For osteoarthritis and rheumatoid arthritis:
  - Adults—At first, 1000 milligrams (mg) once a day, in the morning or evening, or 500 mg twice a day, in the morning and evening. Your doctor may increase the dose, if necessary, up to a total of 2000 mg a day.
  - Children—Use and dose must be determined by your doctor .

Missed Dose

If you miss a dose of nabumetone, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using nabumetone

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood and urine tests may be needed to check for unwanted effects .

nabumetone may raise your risk of having a heart attack or stroke. This is more likely in people who already have heart disease. People who use nabumetone for a long time might also have a higher risk .

nabumetone may cause bleeding in your stomach or intestines. These problems can happen without warning signs. This is more likely if you have had a stomach ulcer in the past, if you smoke or drink alcohol regularly, if you are over 60 years old, if you are in poor health, or if you are using certain other medicines (a steroid or a blood thinner) .

Serious skin reactions can occur during treatment with nabumetone. Check with your doctor right away if you have any of the following symptoms while taking nabumetone: blistering, peeling, loosening of skin, chills, cough, diarrhea, fever, itching, joint or muscle pain, red skin lesions, sore throat, sores, ulcers, or white spots in mouth or on lips, or unusual tiredness or weakness .

Possible warning signs of some serious side effects that can occur during treatment with nabumetone may include swelling of the face, fingers, feet, and/or lower legs; severe stomach pain, black, tarry stools, and/or vomiting of blood or material that looks like coffee grounds; unusual weight gain; yellow skin or eyes; decreased urination; unusual bleeding or bruising; and/or skin rash. Also, signs of serious heart problems could occur such as chest pain, tightness in chest, fast or irregular heartbeat, unusual flushing or warmth of skin, weakness, or slurring of speech. Stop taking nabumetone and check with your doctor immediately if you notice any of these warning signs .

nabumetone may also cause a serious type of allergic reaction called anaphylaxis. Although this is rare, it may occur more often in patients who are allergic to aspirin or to any of the nonsteroidal anti-inflammatory drugs. Anaphylaxis requires immediate medical attention. The most serious signs of this reaction are very fast or irregular breathing, gasping for breath, wheezing, or fainting. Other signs may include changes in color of the skin of the face; very fast but irregular heartbeat or pulse; hive-like swellings on the skin; and puffiness or swellings of the eyelids or around the eyes. If these effects occur, get emergency help at once .

Using nabumetone while you are pregnant can harm your unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away .

nabumetone may make your skin more sensitive to sunlight. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds .

Before having any kind of surgery or medical tests, tell your doctor that you are taking nabumetone. It may be necessary for you to stop treatment for a while, or to change to a different nonsteroidal anti-inflammatory drug before your procedure .

nabumetone Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Headache

itching skin

nausea

rash

stomach pain

swelling

Less common

Burning feeling in chest or stomach

indigestion

stomach upset

swelling or inflammation of the mouth

tenderness in stomach area

vomiting

Rare

Bleeding gums

blistering, peeling, loosening of skin

bloody or black, tarry stools

bloody or cloudy urine

burning upper abdominal pain

changes in vision

chest pain

chills

clay-colored stools

constipation

cough

dark-colored urine

diarrhea

difficult or labored breathing

difficulty swallowing

dizziness

dry cough

dry mouth

fast heartbeat

fever

fluid-filled skin blisters

general feeling of tiredness or weakness

greatly decreased frequency of urination or amount of urine

high blood pressure

hives or welts

increased sensitivity of skin to sunlight

increased thirst

joint pain, stiffness, or swelling

large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs

light-colored stools

loss of appetite

muscle pain

pain in lower back or side

pinpoint red spots on skin

puffiness or swelling of the eyelids or around the eyes, face, lips or tongue

rapid breathing

red irritated eyes

red skin lesions, often with a purple center

redness or other discoloration of skin

severe or continuing stomach pain

severe sunburn

shortness of breath

skin thinness

sore throat

sores, ulcers, or white spots in mouth or on lips

stomach bloating, burning, or cramping

swelling of face, fingers, feet or lower legs

tightness in chest

unpleasant breath odor

unusual bleeding or bruising

unusual tiredness or weakness

vaginal bleeding

vomiting of blood or material that looks like coffee grounds

weight gain or loss

wheezing

yellow eyes or skin

Symptoms of overdose

Agitation

blurred vision

coma

confusion

depression

hostility

irregular, fast or slow, or shallow breathing

irritability

muscle twitching

nervousness

pain or discomfort in chest, upper stomach, or throat

pale or blue lips, fingernails, or skin

pounding in the ears

seizures

severe stomach pain

slow heartbeat

stupor

unusual drowsiness, dullness, or feeling of sluggishness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Acid or sour stomach

belching

bloated full feeling

continuing ringing or buzzing or other unexplained noise in ears

excess air or gas in stomach or intestines

hearing loss

indigestion

mild diarrhea

passing gas

Less common

Increased sweating

sleepiness or unusual drowsiness

sleeplessness

trouble sleeping

unable to sleep

Rare

Anxiety

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

feeling of constant movement of self or surroundings

general feeling of discomfort or illness

increased appetite

lack or loss of strength

lightheadedness

sensation of spinning

shakiness in legs, arms, hands, feet

trembling or shaking of hands or feet

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: nabumetone side effects (in more detail)

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More nabumetone resources

Nabumetone Side Effects (in more detail)
Nabumetone Dosage
Nabumetone Use in Pregnancy & Breastfeeding
Drug Images
Nabumetone Drug Interactions
Nabumetone Support Group
30 Reviews for Nabumetone - Add your own review/rating

Nabumetone Prescribing Information (FDA)

Nabumetone Professional Patient Advice (Wolters Kluwer)

Nabumetone Monograph (AHFS DI)

Nabumetone MedFacts Consumer Leaflet (Wolters Kluwer)

Relafen Consumer Overview

Relafen Prescribing Information (FDA)

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Wednesday, March 7, 2012

Nabumetone