Tusso-DF

Generic Name: guaifenesin and hydrocodone (gwye FEN e sin and HYE droe KOE done)

Brand Names: A-Cof DH, Canges-XP, Codiclear DH, Condasin, Cotuss V, Execlear, Extendryl HC, Hycotuss Expectorant, Hydrocod-GF, Kwelcof, Monte-G HC, Narcof, Pancof XP, Pneumotussin 2.5, Relasin-HCX, Touro HC, Tussicle, Tusso-DF, Vi-Q-Tuss, Vitussin Expectorant, Xpect-HC, Z-Cof HCX

What is Tusso-DF (guaifenesin and hydrocodone)?

Guaifenesin is an expectorant. It helps loosen congestion in your chest and throat, making it easier to cough out through your mouth.

Hydrocodone is a narcotic cough suppressant.

Guaifenesin and hydrocodone is used to treat cough and reduce chest congestion caused by the common cold, flu, or allergies.

Guaifenesin and hydrocodone may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Tusso-DF (guaifenesin and hydrocodone)?

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Drinking alcohol can increase certain side effects of guaifenesin and hydrocodone. Tell your doctor if you regularly use other medicines that make you sleepy (such as other cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by guaifenesin and hydrocodone. Hydrocodone may be habit-forming and should be used only by the person it was prescribed for. Keep the medication in a secure place where others cannot get to it.

What should I discuss with my healthcare provider before taking Tusso-DF (guaifenesin and hydrocodone)?

Hydrocodone may be habit forming and should be used only by the person it was prescribed for. Never share this medication with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. Do not use this medicine if you are allergic to hydrocodone or guaifenesin.

To make sure you can safely take guaifenesin and hydrocodone, tell your doctor if you have any of these other conditions:

• 
  

  liver or kidney disease;

  
  


• 
  

  asthma;

  
  


• 
  

  urination problems;

  
  


• 
  

  an enlarged prostate;

  
  


• 
  

  a thyroid disorder;

  
  


• 
  

  seizures or epilepsy;

  
  


• 
  

  gallbladder disease;

  
  


• 
  

  a head injury; or

  
  


• 
  

  Addison's disease.

  
  

FDA pregnancy category C. It is not known whether this medication will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Guaifenesin and hydrocodone can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take Tusso-DF (guaifenesin and hydrocodone)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Guaifenesin and hydrocodone can be taken with or without food.

Measure liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Call your doctor if your symptoms do not improve, or if they get worse. Store at room temperature away from moisture and heat.

Keep track of the amount of medicine used from each new bottle. Guaifenesin and hydrocodone is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include extreme drowsiness, sweating, pinpoint pupils, nausea, vomiting, dry mouth, confusion, cold and clammy skin, muscle weakness, fainting, weak pulse, slow heart rate, seizure (convulsions), weak or shallow breathing, or breathing that stops.

What should I avoid while taking Tusso-DF (guaifenesin and hydrocodone)?

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Drinking alcohol can increase certain side effects of guaifenesin and hydrocodone.

Ask a doctor or pharmacist before using any other cough, cold, allergy, pain, or sleep medicine. Guaifenesin is contained in many combination medicines. Taking certain products together can cause you to get too much guaifenesin. Check the label to see if a medicine contains guaifenesin.

Tusso-DF (guaifenesin and hydrocodone) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have a serious side effect such as:

• 
  

  slow heart rate, weak or shallow breathing;

  
  


• 
  

  feeling like you might pass out;

  
  


• 
  

  confusion, fear, unusual thoughts or behavior;

  
  


• 
  

  seizure (convulsions); or

  
  


• 
  

  urinating less than usual or not at all.

  
  

Less serious side effects may include:

• 
  

  dizziness, drowsiness;

  
  


• 
  

  nausea, vomiting, upset stomach;

  
  


• 
  

  blurred vision;

  
  


• 
  

  constipation;

  
  


• 
  

  dry mouth; or

  
  


• 
  

  sweating.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Tusso-DF (guaifenesin and hydrocodone)?

Tell your doctor if you regularly use other medicines that make you sleepy (such as other cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by guaifenesin and hydrocodone.

Tell your doctor about all other medicines you use, especially:

• 
  

  antidepressants such as amitriptyline (Elavil, Vanatrip, Limbitrol), doxepin (Sinequan), nortriptyline (Pamelor), and others;

  
  


• 
  

  atropine (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), glycopyrrolate (Robinul), mepenzolate (Cantil), methscopolamine (Pamine), or scopolamine (Transderm-Scop);

  
  


• 
  

  bladder or urinary medications such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), tolterodine (Detrol), or solifenacin (Vesicare);

  
  


• 
  

  a bronchodilator such as ipratropium (Atrovent) or tiotropium (Spiriva); or

  
  


• 
  

  irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Anaspaz, Cystospaz, Levsin, and others), or propantheline (Pro-Banthine).

  
  

This list is not complete and other drugs may interact with guaifenesin and hydrocodone. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Tusso-DF resources

• Tusso-DF Side Effects (in more detail)
• Tusso-DF Use in Pregnancy & Breastfeeding
• Tusso-DF Drug Interactions
• Tusso-DF Support Group
• 0 Reviews for Tusso-DF - Add your own review/rating

• CodiCLEAR DH Liquid MedFacts Consumer Leaflet (Wolters Kluwer)


• Entuss Liquid MedFacts Consumer Leaflet (Wolters Kluwer)


• Tusso-HC Sustained-Release Tablets MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Tusso-DF with other medications

• Cough

Where can I get more information?

• Your pharmacist can provide more information about guaifenesin and hydrocodone.

See also: Tusso-DF side effects (in more detail)

Tegretol

Pronunciation: KAR-ba-MAZ-e-peen
Generic Name: Carbamazepine
Brand Name: Examples include Epitol and Tegretol

Tegretol may rarely cause severe blood problems (eg, aplastic anemia, agranulocytosis). Contact your doctor right away if you develop fever, chills, or sore throat; rash; ulcers or sores in the mouth; unusual bruising or bleeding; unusual tiredness; or swollen lymph nodes. Lab tests, including complete blood cell counts, will be performed before and during treatment with Tegretol. These tests will be used to check for side effects.

Tegretol may rarely cause serious and sometimes fatal skin reactions. Contact your doctor at once if you develop red, swollen, blistered, or peeling skin with or without fever. The risk of this reaction may be greater in Asian patients. Asian patients may need to have a blood test before they start Tegretol to determine whether they have a greater risk of developing a severe skin reaction.

Tegretol is used for:

Treating certain types of seizures. It is also used to treat severe pain of the jaw or cheek caused by a facial nerve problem (trigeminal neuralgia). It may also be used for other conditions as determined by your doctor.

Tegretol is an anticonvulsant. It works to control seizures by blocking certain nerve impulses in the brain. It works to treat trigeminal neuralgia by altering nerve impulses in certain facial nerves, which relieves pain.

Do NOT use Tegretol if:

• you are allergic to any ingredient in Tegretol


• you are allergic to tricyclic antidepressants (eg, amitriptyline), cyclobenzaprine, or similar medicines


• you have a history of bone marrow problems, the blood disorder porphyria, or other serious blood disorders


• you are taking nefazodone


• you are taking a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) or have taken an MAOI within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Video: Treatment for Depression

Treatments for depression are getting better everyday and there are things you can start doing right away.

Before using Tegretol:

Some medical conditions may interact with Tegretol. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you are allergic to other seizure medicines (eg, phenytoin, phenobarbital)


• if you have a history of other types of seizures (eg, absence, atonic), increased pressure in the eye (eg, glaucoma), liver or kidney problems, mood or mental problems, suicidal thoughts or actions, or multiple sclerosis


• if you have a history of heart problems (eg, heart failure, heart block, irregular heartbeat), an abnormal electrocardiogram (ECG), high blood pressure, or high blood cholesterol


• if you have a history of blood problems, including blood problems caused by other medicine


• if you have been tested and know whether or not you have a gene type called HLA-B*1502


• if you have previously taken Tegretol

Some MEDICINES MAY INTERACT with Tegretol. Tell your health care provider if you are taking any other medicines, especially any of the following:

• MAOIs (eg, phenelzine) because a severe reaction, including severe high blood pressure and high fever, may occur


• Nefazodone because its effectiveness may be decreased by Tegretol


• Many other prescription and nonprescription medicines (eg, used for allergies, asthma, blood thinning, cancer, diabetes, infections, inflammation, aches and pains, heartburn or reflux disease, high blood pressure, heart problems, high cholesterol, birth control, hormone replacement, immune system suppression, mental or mood problems, sleep, seizures), multivitamin products, and herbal or dietary supplements (eg, herbal teas, coenzyme Q10, garlic, ginseng, ginkgo, St. John's wort) may also interact with Tegretol. Ask your doctor or pharmacist if you are unsure if any of your medicines might interfere with Tegretol

This may not be a complete list of all interactions that may occur. Ask your health care provider if Tegretol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Tegretol:

Use Tegretol as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Tegretol comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Tegretol refilled.


• Take Tegretol by mouth with food.


• Eating grapefruit or drinking grapefruit juice may increase the risk of Tegretol's side effects. Talk with your doctor before including grapefruit or grapefruit juice in your diet.


• Do not suddenly stop taking Tegretol. You may have an increased risk of seizures. If you need to stop Tegretol or add a new medicine, your doctor will gradually lower your dose.


• Take Tegretol on a regular schedule to get the most benefit from it.


• Taking Tegretol at the same time each day will help you remember to take it.


• Continue to take Tegretol even if you feel well. Do not miss any doses.


• If you miss a dose of Tegretol, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Tegretol.

Important safety information:

• Tegretol may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Tegretol with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Check with your doctor before you drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are taking Tegretol; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.


• Do not take more than the recommended dose without checking with your doctor.


• Patients who take Tegretol may be at increased risk of suicidal thoughts or actions. The risk may be greater in patients who have had suicidal thoughts or actions in the past. Watch patients who take Tegretol closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.


• Tegretol may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.


• Tegretol may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.


• Tegretol may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Tegretol. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.


• Tell your doctor or dentist that you take Tegretol before you receive any medical or dental care, emergency care, or surgery.


• Patients who have a certain gene type called HLA-B*1502 may have an increased risk of serious skin reactions from Tegretol. This gene type is found most commonly in Asian patients. Tell your doctor if you have been tested and know whether or not you have the HLA-B*1502 gene type. Discuss any questions or concerns with your doctor.


• Do not switch from the tablet form of Tegretol to the suspension form without checking with your doctor. The same dose may not have the same effects.


• Tegretol may interfere with certain lab tests, including thyroid function tests. Be sure your doctor and lab personnel know you are using Tegretol.


• Hormonal birth control (eg, birth control pills) may not work as well while you are using Tegretol. To prevent pregnancy, use an extra form of birth control (eg, condoms).


• Tegretol may interfere with some pregnancy test results. Check with your doctor if you have questions or concerns about your pregnancy test results.


• Lab tests, including complete blood cell counts, liver and kidney function, eye exams, and carbamazepine blood levels, may be performed while you take Tegretol. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Tegretol with caution in the ELDERLY; they may be more sensitive to its effects, especially agitation or confusion.


• PREGNANCY and BREAST-FEEDING: Tegretol has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Tegretol while you are pregnant. Tegretol is found in breast milk. Do not breast-feed while taking Tegretol.

Possible side effects of Tegretol:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; drowsiness; dry mouth; nausea; unsteadiness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry, or bloody stools; calf pain, swelling, or tenderness; change in the amount of urine produced; chest pain; confusion; dark urine; decreased coordination; fainting; fast, slow, or irregular heartbeat; fever, chills, or sore throat; hallucinations; joint pain; light-headedness; loss of appetite; menstrual changes; new or worsening mental or mood changes (eg, aggression, agitation, anger, anxiety, depression, irritability, restlessness); pain, tenderness, or unusual swelling in the neck, groin, or under the arms; red or purple spots on your body; red, swollen, blistered, or peeling skin; severe or persistent dizziness or headache; severe or persistent nausea or vomiting; shortness of breath; speech problems; stomach pain; sudden, unusual weight gain; suicidal thoughts or actions; swelling of the hands, ankles, or feet; swollen lymph nodes; trouble sleeping; ulcers or sores in the mouth; uncontrolled muscle movements; unusual bruising or bleeding (eg, bleeding gums, nosebleeds); unusual tiredness or weakness; vision or eye problems; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Tegretol side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include decreased urination; fainting; fast or irregular heartbeat; loss of consciousness; muscle twitching or tremor; seizures; severe dizziness, headache, or drowsiness; severe nausea or vomiting; slow, shallow, or irregular breathing.

Proper storage of Tegretol:

Store Tegretol at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Tegretol out of the reach of children and away from pets.

General information:

• If you have any questions about Tegretol, please talk with your doctor, pharmacist, or other health care provider.


• Tegretol is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Tegretol. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Tegretol resources

• Tegretol Side Effects (in more detail)
• Tegretol Dosage
• Tegretol Use in Pregnancy & Breastfeeding
• Drug Images
• Tegretol Drug Interactions
• Tegretol Support Group
• 36 Reviews for Tegretol - Add your own review/rating

• Tegretol Prescribing Information (FDA)


• Tegretol Advanced Consumer (Micromedex) - Includes Dosage Information


• Tegretol Consumer Overview


• Carbamazepine Prescribing Information (FDA)


• Carbamazepine Professional Patient Advice (Wolters Kluwer)


• Carbamazepine Monograph (AHFS DI)


• Carbatrol Prescribing Information (FDA)


• Epitol Prescribing Information (FDA)


• Equetro Consumer Overview


• Equetro Prescribing Information (FDA)

Compare Tegretol with other medications

• Bipolar Disorder
• Diabetic Nerve Damage
• Dystonia
• Epilepsy
• Peripheral Neuropathy
• Reflex Sympathetic Dystrophy Syndrome
• Schizoaffective Disorder
• Trigeminal Neuralgia
• Vulvodynia

Sabril

Generic Name: vigabatrin (vye GA ba trin)

Brand Names: Sabril

What is vigabatrin?

Vigabatrin is an anti-epileptic medication, also called an anticonvulsant.

Vigabatrin is used in combination with other medications to treat complex partial seizures in adults and adolescents who are at least 16 years old. Vigabatrin is usually given after other anti-epileptic medications have been tried without successful control of seizures.

The powder form of vigabatrin is used to treat infantile spasms in babies and children between the ages of 1 month and 2 years.

Vigabatrin may also be used for purposes not listed in this medication guide.

What is the most important information I should know about vigabatrin?

Before you take vigabatrin, tell your doctor if you have any vision problems, such as retinitis or glaucoma. Some people taking vigabatrin have developed mild to severe vision problems. Vision loss caused by vigabatrin may be permanent, and you must have eye exams on a regular basis while taking this medication.

To be sure vigabatrin is not causing harmful effects on your vision, you will need a thorough eye exam when you start taking the medication and then every 3 months during treatment. If you ever stop taking vigabatrin, you may still need to have eye exams every 3 to 6 months after your treatment ends. Do not miss any follow-up visits to your doctor.

Tell your doctor about all other medications you use.

You may have thoughts about suicide while taking vigabatrin. Your doctor will need to check your progress at regular visits. Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, depression, or thoughts about suicide or hurting yourself.

Vigabatrin is available only under a special program called SHARE. You must be registered in the program and sign documents stating that you understand the risks and benefits of taking this medication and that you agree to have vision exams on a regular basis while you are taking vigabatrin.

What should I discuss with my health care provider before taking vigabatrin?

Some people taking vigabatrin have developed mild to severe vision problems. Vision problems may occur within weeks to years after you start taking vigabatrin. Vision loss caused by vigabatrin may be permanent, and you may notice only mild symptoms of the onset of vision loss. You must have eye exams on a regular basis while taking this medication. Vigabatrin is available only under a special program called SHARE. You must be registered in the program and sign documents stating that you understand the risks and benefits of taking this medication and that you agree to have vision exams every 3 months while you are taking vigabatrin. Ask your doctor or call the drug maker if you have questions about the program or the written requirements. You should not use this medication if you are allergic to vigabatrin.

To make sure you can safely take vigabatrin, tell your doctor if you have any of these other conditions:

• kidney disease;


• 
  

  vision problems, such as retinitis or glaucoma; or

  
  


• 
  

  if you are pregnant or plan to become pregnant while using vigabatrin.

  
  

You may have thoughts about suicide while taking this medication. Your doctor will need to check your progress at regular visits. Do not miss any scheduled appointments.

FDA pregnancy category C. It is not known whether vigabatrin will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Although vigabatrin might harm an unborn baby, having a seizure during pregnancy could harm both mother and baby. If you become pregnant while taking vigabatrin, do not stop taking it without your doctor's advice. If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of vigabatrin on the baby. Vigabatrin can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using vigabatrin.

How should I take vigabatrin?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose over several weeks or months to make sure you get the best results from this medication.

Vigabatrin may be taken with or without food.

Vigabatrin powder must be mixed with water before you give it to a child. Empty the packet of powder into an empty cup and add 10 milliliters (2 teaspoons) of water that is cold or room temperature. If your doctor has prescribed more than 1 packet per dose, use 2 teaspoons of water for each packet of powder you are mixing.

Do not mix the powder and water until you are ready to give a dose. Stir the mixture until the powder dissolves completely. Give the liquid mixture to your child using the 10 mL oral syringe that comes with the medicine. If your child's dose is more than 1 packet, you will need to fill the syringe once for each packet mixed.

To be sure this medication is not causing harmful effects on your vision, you will need a thorough eye exam when you start taking vigabatrin and then every 3 months during treatment. If you ever stop taking vigabatrin, you may still need to have eye exams every 3 to 6 months after your treatment ends. Do not miss any follow-up visits to your doctor.

Do not stop using vigabatrin without first talking to your doctor, even if you feel fine. You may have increased seizures if you stop using vigabatrin suddenly. You may need to use less and less before you stop the medication completely. It may take up to 3 months before your seizure control improves. Contact your doctor if your seizures get worse or you have them more often while taking vigabatrin. Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe drowsiness or dizziness, confusion, trouble speaking, feeling agitated or irritable, unusual thoughts or behavior, increased seizures, slow heart rate, weak or shallow breathing, or fainting.

What should I avoid while taking vigabatrin?

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Vigabatrin side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

• 
  

  any change in your vision, no matter how mild;

  
  


• 
  

  back and forth eye movements you cannot control;

  
  


• 
  

  tremors;

  
  


• 
  

  pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;

  
  


• 
  

  worsening seizures; or

  
  


• 
  

  confusion, mood or behavior changes, depression, thoughts about suicide or hurting yourself.

  
  

Less serious side effects may include:

• 
  

  headache, feeling irritable;

  
  


• 
  

  dizziness, drowsiness, tired feeling;

  
  


• 
  

  memory problems;

  
  


• 
  

  weight gain, swelling anywhere in your body;

  
  


• 
  

  numbness, burning pain, or tingly feeling in your hands or feet;

  
  


• 
  

  loss of coordination;

  
  


• 
  

  joint pain;

  
  


• 
  

  cold symptoms such as stuffy nose, fever, sneezing, sore throat;

  
  


• 
  

  nausea, vomiting, diarrhea; or

  
  


• 
  

  sleep problems (insomnia).

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect vigabatrin?

Cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for depression or anxiety can add to sleepiness caused by vigabatrin. Tell your doctor if you regularly use any of these medicines, or any other seizure medications.

Tell your doctor about all other medications you use, especially:

• 
  

  amiodarone (Cordarone, Pacerone);

  
  


• 
  

  clonazepam (Klonopin);

  
  


• 
  

  deferoxamine (Desferal);

  
  


• 
  

  ethambutol (Myambutol);

  
  


• 
  

  hydroxychloroquine (Plaquenil);

  
  


• 
  

  phenytoin (Dilantin);

  
  


• 
  

  tamoxifen (Soltamox); or

  
  


• 
  

  steroid medicine such as prednisone (Deltasone, Sterapred), budesonide (Pulmicort, Rhinocort, Symbicort), fluticasone (Advair , Flonase, Flovent, Veramyst), mometasone (Asmanex, Nasonex), triamcinolone (Nasacort), and others.

  
  

This list is not complete and other drugs may interact with vigabatrin. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Sabril resources

• Sabril Side Effects (in more detail)
• Sabril Use in Pregnancy & Breastfeeding
• Sabril Drug Interactions
• Sabril Support Group
• 0 Reviews for Sabril - Add your own review/rating

• Sabril Prescribing Information (FDA)


• Sabril Consumer Overview


• Sabril Advanced Consumer (Micromedex) - Includes Dosage Information


• Sabril MedFacts Consumer Leaflet (Wolters Kluwer)


• Vigabatrin Professional Patient Advice (Wolters Kluwer)

Compare Sabril with other medications

• Epilepsy
• Seizure Prevention
• Seizures

Where can I get more information?

• Your pharmacist can provide more information about vigabatrin.

See also: Sabril side effects (in more detail)

SfRowasa

Generic Name: mesalamine (Rectal route)

me-SAL-a-meen

Commonly used brand name(s)

In the U.S.

• Canasa


• Rowasa


• sfRowasa

In Canada

• Mesasal


• Pentasa


• Salofalk

Available Dosage Forms:

• Suppository


• Enema

Therapeutic Class: Gastrointestinal Agent

Chemical Class: Salicylate, Non-Aspirin

Uses For sfRowasa

Mesalamine is used to treat inflammatory bowel disease, such as ulcerative colitis. This medicine works inside the bowel by helping to reduce inflammation and other symptoms.

Mesalamine is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, mesalamine is used in certain patients with the following medical condition:

• Ulcerative colitis, history of—prevent it from occurring again

Before Using sfRowasa

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of mesalamine in children with use in other age groups.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of mesalamine in the elderly with use in other age groups.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	B	Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Varicella Virus Vaccine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Ardeparin


• Certoparin


• Dalteparin


• Danaparoid


• Enoxaparin


• Nadroparin


• Parnaparin


• Reviparin


• Tamarind


• Tinzaparin


• Warfarin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Kidney disease—The use of mesalamine may make this condition worse.

Proper Use of mesalamine

This section provides information on the proper use of a number of products that contain mesalamine. It may not be specific to sfRowasa. Please read with care.

For best results, empty your bowel just before using the rectal enema or suppository.

Keep using this medicine for the full time of treatment even if you begin to feel better after a few days. Do not miss any doses.

For patients using the enema form of this medicine:

• This medicine usually comes with patient directions. Read them carefully before using this medicine.


• Remove the bottles from the protective foil pouch, being careful not to squeeze or puncture them. The enema is an off-white to tan color. Contents of the enemas removed from the foil pouch may darken with time. Slight darkening will not affect the potency of the contents. However, enemas with dark brown contents should be discarded.


• Shake the bottle well to make sure that the medication is thoroughly mixed. Remove the protective cover from the applicator tip. Hold bottle at the neck so that no medicine spills out.


• Lie on your left side with your left leg straight and your right knee bent in front of you for balance. You can also lie in the knee-chest position, on your knees with your chest touching the bed.


• Gently insert the rectal tip of the enema applicator pointed slightly toward your naval to prevent damage to the rectal wall. Tilt the nozzle slightly toward the back and squeeze slowly to cause the enema to flow into your rectum. Steady pressure will discharge most of the medicine. After administering, withdraw and discard the bottle.


• Remain in position for at least 30 minutes to allow the medicine to distribute thoroughly. Retain the medicine all night if possible.

For patients using the suppository form of this medicine:

• This medicine usually comes with patient directions. Read them carefully before using this medicine.


• Detach one suppository from strip of suppositories. Hold suppository upright and carefully remove the foil wrapper.


• Avoid excessive handling of the suppository, which is designed to melt at body temperature.


• Insert suppository (pointed end first) completely into rectum with gentle pressure. Retain the suppository for 3 hours or longer, if possible, to achieve the best result.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For inflammatory bowel disease:
  
  • For enema dosage form:
    
    • Adults and teenagers—4 grams (1 unit), used as directed, every night for three to six weeks.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  
  • For suppository dosage form:
    
    • Adults and teenagers—500 milligrams (mg), inserted into your rectum, two or three times a day for three to six weeks or 1000 mg, inserted into your rectum, one time a day at bedtime for three to six weeks.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using sfRowasa

It is important that your doctor check your progress at regular visits.

Contact your doctor if you develop cramping, acute abdominal pain, bloody diarrhea, fever, headache or rash. These may be symptoms of a serious condition.

Tell your doctor right away if you experience chest pain or shortness of breath.

Check with your doctor if you notice rectal bleeding, blistering, pain, burning, itching, or other sign of irritation not present before you started using this medicine.

Mesalamine rectal enema may stain clothing, fabrics, painted surfaces, marble, granite, vinyl, or other surfaces it touches.

sfRowasa Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Less common or rare

• Abdominal or stomach cramps or pain (severe)


• anxiety


• back pain (severe)


• bloody, black, or tarry stools


• blue or pale skin


• bright red blood in the stool


• chest pain, possibly moving to the left arm, neck, or shoulder


• chills


• diarrhea (severe)


• fast heartbeat


• fever


• headache (severe)


• nausea or vomiting


• shortness of breath


• skin rash


• stomach cramps, tenderness, pain


• swelling of the stomach


• unusual tiredness or weakness


• watery or bloody diarrhea


• yellow eyes or skin

Incidence not known

• Blood in urine


• change in frequency of urination or amount of urine


• cough


• difficulty in breathing


• drowsiness


• high fever


• increased thirst


• loss of appetite


• lower back or side pain


• painful or difficult urination


• pale skin


• sore throat


• sores, ulcers, or white spots on lips or in mouth


• swelling of feet or lower legs


• swollen glands


• troubled breathing


• unexplained or unusual bleeding or bruising


• weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Abdominal or stomach cramps or pain (mild)


• gas or flatulence


• headache (mild)


• nausea

Less common or rare

• Acne


• diarrhea


• dizziness


• leg or joint pain


• loss of hair


• rectal pain or irritation

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: sfRowasa side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More sfRowasa resources

• SfRowasa Side Effects (in more detail)
• SfRowasa Use in Pregnancy & Breastfeeding
• SfRowasa Drug Interactions
• SfRowasa Support Group
• 88 Reviews for SfRowasa - Add your own review/rating

• sfRowasa Prescribing Information (FDA)


• Mesalamine Monograph (AHFS DI)


• Mesalamine Prescribing Information (FDA)


• Mesalamine Controlled-Release Capsules MedFacts Consumer Leaflet (Wolters Kluwer)


• Apriso Prescribing Information (FDA)


• Apriso Extended-Release Capsules MedFacts Consumer Leaflet (Wolters Kluwer)


• Apriso Consumer Overview


• Asacol Prescribing Information (FDA)


• Asacol Consumer Overview


• Asacol Delayed-Release Tablets MedFacts Consumer Leaflet (Wolters Kluwer)


• Asacol HD Prescribing Information (FDA)


• Asacol HD Delayed-Release Tablets MedFacts Consumer Leaflet (Wolters Kluwer)


• Canasa Suppositories MedFacts Consumer Leaflet (Wolters Kluwer)


• Canasa Prescribing Information (FDA)


• Lialda Prescribing Information (FDA)


• Lialda Consumer Overview


• Pentasa Prescribing Information (FDA)


• Pentasa Consumer Overview


• Rowasa Enema MedFacts Consumer Leaflet (Wolters Kluwer)


• Rowasa Prescribing Information (FDA)

Compare sfRowasa with other medications

• Crohn's Disease
• Crohn's Disease, Maintenance
• Inflammatory Bowel Disease
• Lymphocytic Colitis
• Ulcerative Colitis
• Ulcerative Colitis, Active
• Ulcerative Colitis, Maintenance
• Ulcerative Proctitis

Nabumetone

nab-UE-me-tone

Oral route(Tablet)

NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may be increased in patients with cardiovascular disease or risk factors for cardiovascular disease. Nabumetone is contraindicated for the treatment of perioperative pain in the setting of CABG surgery. NSAIDs can also cause an increased risk of serious gastrointestinal adverse events especially in the elderly, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal .

Commonly used brand name(s)

In the U.S.

• Relafen

Available Dosage Forms:

• Tablet

Therapeutic Class: Analgesic

Pharmacologic Class: NSAID

Chemical Class: Acetic Acid (class)

Uses For nabumetone

Nabumetone is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain and help relieve symptoms of arthritis (osteoarthritis and rheumatoid arthritis), such as inflammation, swelling, stiffness, and joint pain. nabumetone does not cure arthritis and will help you only as long as you continue to take it .

nabumetone is available only with your doctor's prescription .

Before Using nabumetone

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For nabumetone, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to nabumetone or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of nabumetone in the pediatric population. Safety and efficacy have not been established .

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of nabumetone in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution in patients receiving nabumetone .

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking nabumetone, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using nabumetone with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Ketorolac


• Pentoxifylline

Using nabumetone with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Abciximab


• Ardeparin


• Argatroban


• Beta Glucan


• Bivalirudin


• Certoparin


• Cilostazol


• Citalopram


• Clopidogrel


• Clovoxamine


• Dabigatran Etexilate


• Dalteparin


• Danaparoid


• Desirudin


• Dipyridamole


• Enoxaparin


• Escitalopram


• Femoxetine


• Flesinoxan


• Fluoxetine


• Fluvoxamine


• Fondaparinux


• Ginkgo


• Heparin


• Lepirudin


• Methotrexate


• Nadroparin


• Nefazodone


• Parnaparin


• Paroxetine


• Pemetrexed


• Protein C


• Reviparin


• Rivaroxaban


• Sertraline


• Sibutramine


• Tacrolimus


• Ticlopidine


• Tinzaparin


• Tirofiban


• Vilazodone


• Zimeldine

Using nabumetone with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acebutolol


• Acetohexamide


• Alacepril


• Alprenolol


• Amiloride


• Arotinolol


• Atenolol


• Azilsartan Medoxomil


• Azosemide


• Befunolol


• Bemetizide


• Benazepril


• Bendroflumethiazide


• Benzthiazide


• Betaxolol


• Bevantolol


• Bisoprolol


• Bopindolol


• Bucindolol


• Bumetanide


• Bupranolol


• Buthiazide


• Candesartan Cilexetil


• Canrenoate


• Captopril


• Carteolol


• Carvedilol


• Celiprolol


• Chlorothiazide


• Chlorpropamide


• Chlorthalidone


• Cilazapril


• Clopamide


• Cyclopenthiazide


• Cyclosporine


• Delapril


• Desvenlafaxine


• Dicumarol


• Dilevalol


• Duloxetine


• Enalaprilat


• Enalapril Maleate


• Eprosartan


• Esmolol


• Ethacrynic Acid


• Fosinopril


• Furosemide


• Gliclazide


• Glimepiride


• Glipizide


• Gliquidone


• Glyburide


• Hydrochlorothiazide


• Hydroflumethiazide


• Imidapril


• Indapamide


• Irbesartan


• Labetalol


• Landiolol


• Levobetaxolol


• Levobunolol


• Lisinopril


• Losartan


• Mepindolol


• Methyclothiazide


• Metipranolol


• Metolazone


• Metoprolol


• Milnacipran


• Moexipril


• Nadolol


• Nebivolol


• Nipradilol


• Olmesartan Medoxomil


• Oxprenolol


• Penbutolol


• Pentopril


• Perindopril


• Phenprocoumon


• Pindolol


• Piretanide


• Polythiazide


• Propranolol


• Quinapril


• Ramipril


• Sotalol


• Spirapril


• Spironolactone


• Talinolol


• Tasosartan


• Telmisartan


• Temocapril


• Tertatolol


• Timolol


• Tolazamide


• Tolbutamide


• Torsemide


• Trandolapril


• Triamterene


• Trichlormethiazide


• Valsartan


• Venlafaxine


• Xipamide


• Zofenopril

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of nabumetone. Make sure you tell your doctor if you have any other medical problems, especially:

• Anemia or


• Asthma or


• Bleeding problems or


• Blood clots or


• Edema (fluid retention or body swelling) or


• Heart attack, history of or


• Heart disease (e.g., congestive heart failure) or


• High blood pressure or


• Kidney disease or


• Liver disease (e.g., hepatitis) or


• Stomach or intestinal ulcers or bleeding or


• Stroke, history of—Use with caution. nabumetone may make these conditions worse .

• Aspirin sensitivity, history of—nabumetone should NOT be used in patients with this condition .

• Heart surgery (e.g., coronary artery bypass graft [CABG] surgery)—nabumetone should NOT be used to relieve pain right before or after the surgery .

Proper Use of nabumetone

For safe and effective use of nabumetone, do not take more of it, do not take it more often, and do not take it for a longer time than ordered by your doctor. Taking too much of nabumetone may increase the chance of unwanted effects, especially in elderly patients .

When used for severe or continuing arthritis, nabumetone must be taken regularly as ordered by your doctor in order for it to help you. nabumetone usually begins to work within one week, but in severe cases up to two weeks or even longer may pass before you begin to feel better. Also, several weeks may pass before you feel the full effects of nabumetone.

You may take nabumetone with or without food .

Dosing

The dose of nabumetone will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of nabumetone. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  
  • For osteoarthritis and rheumatoid arthritis:
    
    • Adults—At first, 1000 milligrams (mg) once a day, in the morning or evening, or 500 mg twice a day, in the morning and evening. Your doctor may increase the dose, if necessary, up to a total of 2000 mg a day.
    
    
    • Children—Use and dose must be determined by your doctor .
    
    
  
  

Missed Dose

If you miss a dose of nabumetone, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using nabumetone

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood and urine tests may be needed to check for unwanted effects .

nabumetone may raise your risk of having a heart attack or stroke. This is more likely in people who already have heart disease. People who use nabumetone for a long time might also have a higher risk .

nabumetone may cause bleeding in your stomach or intestines. These problems can happen without warning signs. This is more likely if you have had a stomach ulcer in the past, if you smoke or drink alcohol regularly, if you are over 60 years old, if you are in poor health, or if you are using certain other medicines (a steroid or a blood thinner) .

Serious skin reactions can occur during treatment with nabumetone. Check with your doctor right away if you have any of the following symptoms while taking nabumetone: blistering, peeling, loosening of skin, chills, cough, diarrhea, fever, itching, joint or muscle pain, red skin lesions, sore throat, sores, ulcers, or white spots in mouth or on lips, or unusual tiredness or weakness .

Possible warning signs of some serious side effects that can occur during treatment with nabumetone may include swelling of the face, fingers, feet, and/or lower legs; severe stomach pain, black, tarry stools, and/or vomiting of blood or material that looks like coffee grounds; unusual weight gain; yellow skin or eyes; decreased urination; unusual bleeding or bruising; and/or skin rash. Also, signs of serious heart problems could occur such as chest pain, tightness in chest, fast or irregular heartbeat, unusual flushing or warmth of skin, weakness, or slurring of speech. Stop taking nabumetone and check with your doctor immediately if you notice any of these warning signs .

nabumetone may also cause a serious type of allergic reaction called anaphylaxis. Although this is rare, it may occur more often in patients who are allergic to aspirin or to any of the nonsteroidal anti-inflammatory drugs. Anaphylaxis requires immediate medical attention. The most serious signs of this reaction are very fast or irregular breathing, gasping for breath, wheezing, or fainting. Other signs may include changes in color of the skin of the face; very fast but irregular heartbeat or pulse; hive-like swellings on the skin; and puffiness or swellings of the eyelids or around the eyes. If these effects occur, get emergency help at once .

Using nabumetone while you are pregnant can harm your unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away .

nabumetone may make your skin more sensitive to sunlight. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds .

Before having any kind of surgery or medical tests, tell your doctor that you are taking nabumetone. It may be necessary for you to stop treatment for a while, or to change to a different nonsteroidal anti-inflammatory drug before your procedure .

nabumetone Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Headache


• itching skin


• nausea


• rash


• stomach pain


• swelling

Less common

• Burning feeling in chest or stomach


• indigestion


• stomach upset


• swelling or inflammation of the mouth


• tenderness in stomach area


• vomiting

Rare

• Bleeding gums


• blistering, peeling, loosening of skin


• bloody or black, tarry stools


• bloody or cloudy urine


• burning upper abdominal pain


• changes in vision


• chest pain


• chills


• clay-colored stools


• constipation


• cough


• dark-colored urine


• diarrhea


• difficult or labored breathing


• difficulty swallowing


• dizziness


• dry cough


• dry mouth


• fast heartbeat


• fever


• fluid-filled skin blisters


• general feeling of tiredness or weakness


• greatly decreased frequency of urination or amount of urine


• high blood pressure


• hives or welts


• increased sensitivity of skin to sunlight


• increased thirst


• joint pain, stiffness, or swelling


• large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs


• light-colored stools


• loss of appetite


• muscle pain


• pain in lower back or side


• pinpoint red spots on skin


• puffiness or swelling of the eyelids or around the eyes, face, lips or tongue


• rapid breathing


• red irritated eyes


• red skin lesions, often with a purple center


• redness or other discoloration of skin


• severe or continuing stomach pain


• severe sunburn


• shortness of breath


• skin thinness


• sore throat


• sores, ulcers, or white spots in mouth or on lips


• stomach bloating, burning, or cramping


• swelling of face, fingers, feet or lower legs


• tightness in chest


• unpleasant breath odor


• unusual bleeding or bruising


• unusual tiredness or weakness


• vaginal bleeding


• vomiting of blood or material that looks like coffee grounds


• weight gain or loss


• wheezing


• yellow eyes or skin

Symptoms of overdose

• Agitation


• blurred vision


• coma


• confusion


• depression


• hostility


• irregular, fast or slow, or shallow breathing


• irritability


• muscle twitching


• nervousness


• pain or discomfort in chest, upper stomach, or throat


• pale or blue lips, fingernails, or skin


• pounding in the ears


• seizures


• severe stomach pain


• slow heartbeat


• stupor


• unusual drowsiness, dullness, or feeling of sluggishness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Acid or sour stomach


• belching


• bloated full feeling


• continuing ringing or buzzing or other unexplained noise in ears


• excess air or gas in stomach or intestines


• hearing loss


• indigestion


• mild diarrhea


• passing gas

Less common

• Increased sweating


• sleepiness or unusual drowsiness


• sleeplessness


• trouble sleeping


• unable to sleep

Rare

• Anxiety


• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings


• feeling of constant movement of self or surroundings


• general feeling of discomfort or illness


• increased appetite


• lack or loss of strength


• lightheadedness


• sensation of spinning


• shakiness in legs, arms, hands, feet


• trembling or shaking of hands or feet

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: nabumetone side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More nabumetone resources

• Nabumetone Side Effects (in more detail)
• Nabumetone Dosage
• Nabumetone Use in Pregnancy & Breastfeeding
• Drug Images
• Nabumetone Drug Interactions
• Nabumetone Support Group
• 30 Reviews for Nabumetone - Add your own review/rating

• Nabumetone Prescribing Information (FDA)


• Nabumetone Professional Patient Advice (Wolters Kluwer)


• Nabumetone Monograph (AHFS DI)


• Nabumetone MedFacts Consumer Leaflet (Wolters Kluwer)


• Relafen Consumer Overview


• Relafen Prescribing Information (FDA)

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Trental

Pronunciation: pen-tox-IH-fi-leen
Generic Name: Pentoxifylline
Brand Name: Pentoxil or Trental

Trental is used for:

Treating intermittent claudication (pain, cramping, numbness, or weakness in the foot, hip, thigh, or buttocks) in certain patients. It may also be used for other conditions as determined by your doctor.

Trental is a xanthine derivative blood flow enhancer. It works by thinning the blood and improving red blood cell flexibility, causing the blood to flow more freely through the veins.

Do NOT use Trental if:

• you are allergic to any ingredient in Trental or to methylxanthines (eg, theophylline, caffeine, theobromine)


• you have had recent bleeding in the brain or eye

Contact your doctor or health care provider right away if any of these apply to you.

Before using Trental:

Some medical conditions may interact with Trental. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have ulcers, blood vessel problems, high blood pressure, kidney problems, or a history of bleeding in the eye


• if you have recently had surgery

Some MEDICINES MAY INTERACT with Trental. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticoagulants (eg, warfarin) or theophyllines because the risk of side effects, such as bleeding or toxic effects, may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Trental may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Trental:

Use Trental as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Trental by mouth with food or milk.


• Swallow whole. Do not break, crush, or chew before swallowing.


• If you miss a dose of Trental, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Trental.

Important safety information:

• Trental may cause dizziness or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Trental with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Tell your doctor or dentist that you take Trental before you receive any medical or dental care, emergency care, or surgery.


• It may take 2 to 4 weeks to notice improvement in your condition, and up to 8 weeks for maximum relief.


• Use Trental with caution in the ELDERLY; they may be more sensitive to its effects.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Trental while you are pregnant. Trental is found in breast milk. Do not breast-feed while taking Trental.

Possible side effects of Trental:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Belching; bloating; blurred vision; diarrhea; dizziness; flushing; gas; headache; indigestion; nausea; stomach discomfort.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; irregular heartbeat; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Trental side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include agitation; dizziness; drowsiness; fever; flushing; loss of consciousness; seizures.

Proper storage of Trental:

Store Trental at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Trental out of the reach of children and away from pets.

General information:

• If you have any questions about Trental, please talk with your doctor, pharmacist, or other health care provider.


• Trental is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Trental. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Trental resources

• Trental Side Effects (in more detail)
• Trental Use in Pregnancy & Breastfeeding
• Drug Images
• Trental Drug Interactions
• Trental Support Group
• 2 Reviews for Trental - Add your own review/rating

• Trental Advanced Consumer (Micromedex) - Includes Dosage Information


• Trental Concise Consumer Information (Cerner Multum)


• Trental Prescribing Information (FDA)


• Pentoxifylline Prescribing Information (FDA)


• Pentoxifylline Professional Patient Advice (Wolters Kluwer)


• Pentoxifylline Monograph (AHFS DI)


• Pentoxil Prescribing Information (FDA)

Compare Trental with other medications

• Intermittent Claudication

Simply Stuffy

Generic Name: pseudoephedrine (Oral route)

soo-doe-e-FED-rin

Commonly used brand name(s)

In the U.S.

• 12 Hour Cold Maximum Strength


• Biofed


• Cenafed


• Chlor-Trimeton Nasal Decongestant


• Contac 12-Hour


• Dimetapp Decongestant


• Efidac 24 Pseudoephedrine


• ElixSure Congestion Children's


• Genaphed


• Pediacare Decongestant Infants


• Simply Stuffy


• Sudafed

Available Dosage Forms:

• Capsule, Extended Release


• Tablet, Chewable


• Tablet, Extended Release


• Solution


• Syrup


• Liquid


• Tablet


• Capsule


• Capsule, Liquid Filled


• Suspension

Therapeutic Class: Decongestant

Pharmacologic Class: Alpha-Adrenergic Agonist

Uses For Simply Stuffy

Pseudoephedrine is used to relieve nasal or sinus congestion caused by the common cold, sinusitis, and hay fever and other respiratory allergies. It is also used to relieve ear congestion caused by ear inflammation or infection.

Some of these preparations are available only with your doctor's prescription.

Do not give any over-the-counter (OTC) cough and cold medicine to a baby or child under 4 years of age. Using these medicines in very young children might cause serious or possibly life-threatening side effects .

Before Using Simply Stuffy

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Pseudoephedrine may be more likely to cause side effects in infants, especially newborn and premature infants, than in older children and adults.

Do not give any over-the-counter (OTC) cough and cold medicine to a baby or child under 4 years of age. Using these medicines in very young children might cause serious or possibly life-threatening side effects .

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of pseudoephedrine in the elderly with use in other age groups.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Clorgyline


• Dihydroergotamine


• Furazolidone


• Iproniazid


• Isocarboxazid


• Linezolid


• Moclobemide


• Nialamide


• Pargyline


• Phenelzine


• Procarbazine


• Rasagiline


• Selegiline


• Toloxatone


• Tranylcypromine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Guanethidine


• Methyldopa


• Midodrine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Type 2 diabetes mellitus—Use of pseudoephedrine may cause an increase in blood glucose levels

• Enlarged prostate or


• Glaucoma, or a predisposition to glaucoma or


• Heart disease or blood vessel disease or


• High blood pressure—Pseudoephedrine may make the condition worse

• Overactive thyroid—Use of pseudoephedrine may make the condition worse

Proper Use of pseudoephedrine

This section provides information on the proper use of a number of products that contain pseudoephedrine. It may not be specific to Simply Stuffy. Please read with care.

For patients taking pseudoephedrine extended-release capsules:

• Swallow the capsule whole. However, if the capsule is too large to swallow, you may mix the contents of the capsule with jam or jelly and swallow without chewing.


• Do not crush or chew before swallowing.

For patients taking pseudoephedrine extended-release tablets:

• Swallow the tablet whole.


• Do not break, crush, or chew before swallowing.

To help prevent trouble in sleeping, take the last dose of pseudoephedrine for each day a few hours before bedtime. If you have any questions about this, check with your doctor.

Take this medicine only as directed. Do not take more of it, do not take it more often, and do not take it for a longer period of time than recommended on the label (usually 7 days), unless otherwise directed by your doctor. To do so may increase the chance of side effects.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For nasal or sinus congestion:
  
  • For regular (short-acting) oral dosage form (capsules, oral solution, syrup, or tablets):
    
    • Adults and children 12 years of age and older—60 milligrams (mg) every four to six hours. Do not take more than 240 mg in twenty-four hours.
    
    
    • Children 6 to 12 years of age—30 mg every four to six hours. Do not take more than 120 mg in twenty-four hours.
    
    
    • Children 4 to 6 years of age—15 mg every four to six hours. Do not take more than 60 mg in twenty-four hours.
    
    
    • Children and infants up to 4 years of age—Use is not recommended .
    
    
  
  
  • For long-acting oral dosage form (extended-release capsules or extended-release tablets):
    
    • Adults and children 12 years of age and older—120 mg every 12 hours, or 240 mg every 24 hours. Do not take more than 240 mg in 24 hours.
    
    
    • Infants and children up to 12 years of age—Use is not recommended .
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Simply Stuffy

If symptoms do not improve within 7 days or if you also have a high fever, check with your doctor since these signs may mean that you have other medical problems.

Simply Stuffy Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Rare - more common with high doses

• Convulsions (seizures)


• hallucinations (seeing, hearing, or feeling things that are not there)


• irregular or slow heartbeat


• shortness of breath or troubled breathing

Symptoms of overdose

• Convulsions (seizures)


• fast breathing


• hallucinations (seeing, hearing, or feeling things that are not there)


• increase in blood pressure


• irregular heartbeat (continuing)


• shortness of breath or troubled breathing (severe or continuing)


• slow or fast heartbeat (severe or continuing)


• unusual nervousness, restlessness, or excitement

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Nervousness


• restlessness


• trouble in sleeping

Less common

• Difficult or painful urination


• dizziness or light-headedness


• fast or pounding heartbeat


• headache


• increased sweating


• nausea or vomiting


• trembling


• unusual paleness


• weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Simply Stuffy side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Simply Stuffy resources

• Simply Stuffy Side Effects (in more detail)
• Simply Stuffy Use in Pregnancy & Breastfeeding
• Drug Images
• Simply Stuffy Drug Interactions
• Simply Stuffy Support Group
• 8 Reviews for Simply Stuffy - Add your own review/rating

Compare Simply Stuffy with other medications

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